4 edition of Platinum, gold, and other metal chemotherapeutic agents found in the catalog.
Platinum, gold, and other metal chemotherapeutic agents
|Statement||Stephen J. Lippard, editor.|
|Series||ACS symposium series,, 209|
|Contributions||Lippard, Stephen J., American Chemical Society. Division of Inorganic Chemistry., American Chemical Society. Meeting|
|LC Classifications||RS431.M45 P57 1983|
|The Physical Object|
|Pagination||x, 453 p. :|
|Number of Pages||453|
|LC Control Number||82024333|
spread use as imaging agents for the diagnosis of disease. Many patients admit ted overnight to a hospital in the U.S. will receive an injection of a 99mTc compound for radiodiagnostic purposes. Yet, despite the obvious success of metal complexes as diagnostic and chemotherapeutic agents, few pharmaceutical. Chemotherapeutic agents - Definitions. STUDY. PLAY. chemotherapeutic drugs. agents that affect cells by altering cellular function, disrupting cellular integrity, or preventing cellular reproduction. the ability of a drug to injure a target cell or target organism without injuring other cells or organisms that are in intimate contact with.
Remarkable advances have been achieved in the development of metal NHC complexes as anticancer as well as theranostic agents. NHC complexes of gold, platinum and palladium have been designed to. Also called platinum salts or metal salts. These are alkylating agents. Cisplatin. Brand/Trade Names: Platinol, Cisplatinum, cis-diamminedichloroplatinum(II) Formula: H 6 C l2 N 2 Pt. Mechanism: Alkylating. Class: Platinum salt. Administration: Intravenous. Notes: The “penicillin of cancer”. First used in the s. Approved by the FDA in
Chemotherapeutic Agents. 1. Antibiotics 2. Synthetic Drug. Antibiotics - A chemical substance naturally produced by microorganism that has the capacity to inhibit or kill other microbes. Synthetic Drug. synthesized; can me a modified natural antibiotic (semi-synthetic) Spectrum of Activity. 1. Narrow spectrum 2. Broad spectrum 3. Transition metal complexes as drugs and chemotherapeutic agents. Nicholas Farrell. Kluwer Academic Publishers, - Medical - pages. 0 Reviews. From inside the book. What people are saying - Write a review. We haven't found any reviews in the usual places. Contents. Interaction of Metal Complexes with DNA. 8.
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Platinum, Gold, and Other Metal Chemotherapeutic Agents: Chemistry and Biochemistry (Acs Symposium Series) [Stephen J. (editor) Lippard] on *FREE* shipping on qualifying offers.
Book. Get this from a library. Platinum, gold, and other metal chemotherapeutic agents: chemistry and biochemistry. [Stephen J Lippard; American Chemical Society. Division of Inorganic Chemistry.; American Chemical Society. Meeting;].
Platinum(II) Complex Formation with Uracil and Thymine BERNHARD LIPPERT Chapter 7, DOI: /bkch Publication Date (Print): Janu Transition Metal Complexes as Drugs and Chemotherapeutic Agents (Catalysis by Metal Complexes When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate.
See and discover other Cited by: Get this from a library. Platinum, gold, and other metal chemotherapeutic agents: chemistry and biochemistry: based on a symposium sponsored by the ACS Division of Inorganic Chemistry at the rd Meeting of the American Chemical Society, Las Vegas, Nevada, March 28 - April 2, [Stephen J Lippard; American Chemical Society.
Division of Inorganic Chemistry. This is a list of chemotherapeutic agents, also known as cytotoxic agents, that are known to be of use in chemotherapy for list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision.
Each drug is listed once (at present), though it might fall in more than one subsection. The platinum-containing chemotherapeutic agents remain key components of many of the most effective regimens for the treatment of cancer.
New information about the chemistry, pharmacology and molecular mechanisms by which these drugs work is leading to both the development of new drugs and more effective use of existing members of this class.
When this book was first conceived as a project the expanding interest in the clinical use of platinum and gold complexes made a survey of the relevant biological properties of metal complexes timely and appropriate.
This timeliness has not diminished during the gestation and final publica tion of the manuscript. Platinum-based drugs have become a mainstay of cancer therapy; approximately half of all patients undergoing chemotherapeutic treatment receive a platinum drug ().The widespread use of platinum agents in the treatment of cancer began with the discovery of the antineoplastic activity of cisplatin by Barnett Rosenberg in the s ().Despite the pervasiveness of Cited by: Platinum is a chemical element with the symbol Pt and atomic number It is a dense, malleable, ductile, highly unreactive, precious, silverish-white transition name is derived from the Spanish term platino, meaning "little silver".
Platinum is a member of the platinum group of elements and group 10 of the periodic table of has six naturally occurring ciation: /ˈplætɪnəm/ (PLAT-ə-nəm). Radiodiagnostic Age Metal complexes having radioactive nuclei find many applications in medicine, such as in organ, and tissue imaging, Early detection of cancer, for example, by selective and imaging of the tumor using a radioactive metal compound can facilitate surgical removal or chemotherapeutic treatment before the disease reaches an advanced stage.
Metal-based anticancer chemotherapeutic agents Article Literature Review (PDF Available) in Current opinion in chemical biology 19C(1). Metal Complexes as Drugs and Chemotherapeutic Agents N. FARRELL Virginia Commonwealth University, Richmond, VA, USA INTRODUCTION Biological Assays PLATINUM COMPLEXES AS THERAPEUTIC AGENTS Clinically Used Anticancer Agents.
Cis-platinum Compounds Platinum Compounds in Clinical File Size: KB. Read the Journal Offline; Platinum Metals Rev.,34, (1), 15 Noble Metals in Medicine Transition Metal Complexes as Drugs and Chemotherapeutic Agents By farrell nicholas, Kluwer Academic Publishers, Dordrecht,pages, ISBNDfl.£ As a heavy metal, platinum drugs must have a particular method of entering their cell of interest.
Metal transporters, such as the copper transporters CTR1, ATP7A and ATP7B, have been of particular interest. Deletion of the CTR1 gene in yeast leads to a significant accumulation of all three clinically available platinum agents.
Attempts to incorporate ruthenium into pharmaceutical agents have typically followed two avenues of approach. Early studies were directed toward ruthenium-containing chemotherapeutic agents1 and more recently workers have begun to explore the possibility of using 97Ru for diagnostic organ imaging.2,3 While ruthenium complexes have shown promise along both directions.
Platinum compounds form DNA adducts, which ultimately result in activation of pdependent and pindependent apoptosis. 24 As monotherapy, cisplatin has anticancer activity comparable with that of other single agents, leading to response rates of approximately 15% and a median survival of 6 to 8 months.
21 In order to increase the efficacy. Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat are coordination complexes of drugs are used to treat almost half of people receiving chemotherapy for cancer. In this form of chemotherapy, popular drugs include cisplatin, oxaliplatin, and carboplatin, but several have been proposed or are under.
Platinum containing drugs, such as cisplatin and carboplatin, are used as chemotherapeutic agents. Such drugs are extremely toxic and cause nephrotoxicity with associated magnesium wasting and hypomagnesaemia (low magnesium), myelosuppression, inner ear. Over books relating to gold, silver, platinum, sharemarkets, investing, survival, preparedness.
Remarkable advances have been achieved in the development of metal NHC complexes as anticancer as well as theranostic agents. NHC complexes of gold, platinum and palladium have been designed to elicit potent cancer cell cytotoxicity, effective anti-tumor activities in animal models as well as selective binding to molecular targets (e.g.
protein Cited by: Bruck M. A., Korte H. H., Bau R., Hadjiliadis N. and Boonkong T. "Platinum, Gold, and Other Metal Chemotherapeutic Agents ACS Symposium Series" vol ed S. J. Lippard (Washington) p Crossref Google Scholar.ADVERTISEMENTS: In this article we will discuss about: 1.
Meaning of Chemotherapeutic Agents 2. General Characteristics of Chemotherapeutic Agents 3. Factors that Influence the Effectiveness.
Meaning of Chemotherapeutic Agents: Microbial pathogens grow on and within the body of other living beings and their colonization may lead to disease, disability, and death. .